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KMID : 1123920110250040628
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Korean Journal of Oriental Physiology and Pathology
2011 Volume.25 No. 4 p.628 ~ p.634
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Neuroprotective Effect of the Acid Hydrolysis Fraction of the Roots of Polygala Tenuifolia
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Lee Dong-Sung
Choi Hyun-Gyu
Li Bin
Kim Soon-Ai
Chon Seung-Ki
Rho Jung-Mi
Kim Ki- Mo
Han Jong-Hyun
Jeong Gil-Saeng
Kim Youn-Chul
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Abstract
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The roots of Polygala tenuifolia Willd. is a well-known traditional medicine used as expectorant, tonic, tranquilizer in Asia including China and Korea. And also have been used to treat amnesia, neurasthenia, palpitation, insomnia, and disorientation. Glutamate-induced oxidative injury contributes to neuronal degeneration in many central nervous system (CNS) diseases, such as Parkinson’s disease, Alzheimer’s disease, epilepsy and ischemia. Inducible heme oxygenase (HO)-1 acts against oxidants that are thought to play a role in the pathogenesis of these diseases. NNMBS269, acid hydrolysis EtOAc fraction of the P. tenuifolia showed dominant neuroprotective effects on glutamate-induced neurotoxicity in mouse hippocampal HT22 cells while general EtOAc fraction of the P. tenuifolia (NNMBS268) not shown. NNMBS269 induced the expression of HO-1 protein that has been proposed to play an important cellular defense role against oxidant injury. In addition increased HO activity. In mouse hippocampal HT22 cells, NNMBS269 makes the nuclear accumulation of nuclear factor E2-related factor 2 (Nrf2). In conclusion, acid hydrolysis EtOAc fraction the P. enuifolia. (NNMBS269) significantly protect glutamate-induced oxidative damage by induction of HO-1 via Nrf2 translocation in mouse hippocampal HT22 cells.
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KEYWORD
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polygala tenuifolia, heme oxygenase-1, HT22, glutamate, neuroprotective effect
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